Features
- Fusion Software Supports up to 8 Cages per PC
- Open Circuit Calorimetry without Drierite
- O2/CO2 Analyzers require virtually no calibration
- Oxygen Consumption, VO2
- Carbon Dioxide Production, VCO2
- Respiratory Quotient, VCO2/VO2
- Real Time Plot of All Variables (see Screen Shot)
- Advanced Diagnostic Utilities
- Records Complete Experimental Data
- Comprehensive Variable List with Selectable Units
- Comprehensive Security Features
- Modular and Extensible Fusion Software (XP/Vista Compatible)
- USB Compatible/CE Compliant
Requires
Fusion Software
Can Be Combined With
- Open Field - Locomotor Activity
- Diet - Food/Liquid Consumption
- Mouse/Rat Treadmill Exercise
- Hole Poke - Baited Nose Poke
- Fear Conditioning - Freeze Monitoring
Overview
Fusion Metabolic System uses Open Circuit Calorimetry and is ideal
for measurement of Oxygen Consumption and Carbon Dioxide Production
in lab animals in an open Field or in a Treadmill. With Fusion
Software, the system monitors, records and plots O2, CO2, VO2,
VCO2, RQ measurements every second. Archived Experiments can be
reanalyzed and exported to any spreadsheet/statistical package for
further analysis. Up to eight animals can be simultaneously
monitored. Two, four, and six animal systems are also available.
Components
The Metabolic System is comprised of a Metabolic Analyzer, Oxygen
Analyzer, Carbon Dioxide Analyzer, a multi channel Flow Controller,
Windows XP/Vista Based Fusion Software and air-tight Cages or
Treadmills. The Metabolic System measures and stores O2/CO2 content
and Air Flow of one to eight enclosed environments. The System also
generates and stores VO2, VCO2 and RQ Data for each subject. A
diagnostics mode allows the user to perform a hardware test on the
system to insure proper operating conditions. The Oxygen Analyzer
uses a Zirconia Sensor and has a built in sample pump and flow
controller. The carbon dioxide analyzer has a dual beam sensor and
requires no calibration. The flow controller has independent pumps
for each channel as well as a mass flow meter. Flow Ranges are
adjustable up to 5 L/min for small animals (Mice/Rats) and up to 25
L/min for larger animals (Cats/Dogs/Pigs). The System does not
require the use of Drierite .
Experimental Process
The animal is placed in an air tight cage . Ambient air is pumped
through the cage. The amount of air entering the cage is precisely
measured by a Mass Flow Meter. Air entering and leaving each cage
is monitored for O2 and CO2 content by zirconia and infrared
sensors. Both sensors are very accurate and maintenance free.
Unlike electrochemical cells, zirconia cells provide higher
accuracy and do not have to be replaced. Since the System does not
require the use of Drierite, multi day experiments can be easily
run without user intervention. All Experiment Data is continuously
monitored, displayed and stored for future analysis.
Variables
- Animal Weight (g)
- Reference Flow Rate (mL/min)
- Reference O2%
- Reference CO2%
- Cage Flow Rate(mL/min)
- Cage 02%
- Cage CO2%
- %O2 Change
- %CO2 Change
- VO2 (mL/Kg/min)
- VCO2 (mL/Kg/min)
- Respiratory Quotient (VCO2/VO2)
